A mutant protein of human interleukin-1 beta with immunostimulatory but not pyrogenic potency.

doi:10.1016/0024-3205(90)90343-p

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Article

A mutant protein of human interleukin-1 beta with immunostimulatory but not pyrogenic potency.

Life sciences - 1 Jan 1990

Nakai S, Kawai K, Hirai Y, Tasaka K

Abstract excerpt

Interleukin-1 (IL-1) mediates a variety of immune and inflammatory responses. In order to understand the mechanisms involved in multiple biological functions, it is important to define the active sites of IL-1. Using the technique for site-specific mutagenesis, we tested whether the arginine resi...

Topics

Adjuvants, Immunologic
Animals
Antibody Formation
Humans
Interleukin-1
Interleukin-2
Male
Mice
Mice, Inbred BALB C
Mutation
Pyrogens
Rats
Rats, Inbred Strains
Structure-Activity Relationship

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