Article
A mutant protein of human interleukin-1 beta with immunostimulatory but not pyrogenic potency.
Life sciences - 1 Jan 1990
Nakai S, Kawai K, Hirai Y, Tasaka K
Abstract excerpt
Interleukin-1 (IL-1) mediates a variety of immune and inflammatory responses. In order to understand the mechanisms involved in multiple biological functions, it is important to define the active sites of IL-1. Using the technique for site-specific mutagenesis, we tested whether the arginine residue at the 4th position in human IL-1 beta is essential for multiple biological activities. In our experiments, the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.