Article
An interleukin 5 mutant distinguishes between two functional responses in human eosinophils.
The Journal of experimental medicine - 7 Jul 1997
McKinnon M, Page K, Uings I J, Banks M, Fattah D, Proudfoot A E, Graber P, Arod C, Fish R, Wells T N, Solari R
Abstract excerpt
Interleukin 5 (IL-5) is the key cytokine involved in regulating the production and many of the specialized functions of mature eosinophils including priming, adhesion, and survival. We have generated a point mutant of human IL-5, IL-5 (E12K), which is devoid of agonist activity in both a TF-1 cell proliferation assay and a human eosinophil adhesion assay. However, IL-5 (E12K) is a potent and specific antagonist...
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