Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Development of a human interleukin-6 receptor antagonist.

The Journal of biological chemistry - 7 Jan 1994

Brakenhoff J P, de Hon F D, Fontaine V, ten Boekel E, Schooltink H, Rose-John S, Heinrich P C, Content J, Aarden L A

Abstract excerpt

Neutralizing monoclonal antibodies specific for human interleukin-6 (IL-6) bind two distinct sites on the IL-6 protein (sites I and II). Their interference with IL-6 receptor binding suggested that site I is a receptor-binding site of IL-6, whereas site II is important for signal transduction. Mutagenesis of site II could therefore result in the isolation of IL-6 receptor antagonists. To test this hypothesis, a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Monoclonal
Share to Cell Line
Share to Interleukin-6

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Protein Binding

Share to Receptors, Interleukin

Share to Signal Transduction

Source

Identifiers

PMID: 8276883

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Development of a human interleukin-6 receptor antagonist.PMID 8276883Read ↗

Unveiling novel insights into human IL-6 - IL-6R interaction sites through 3D computer-guided docking and systematic site mutagenesis.Semantic proximity Read ↗

Development of an IL-6 inhibitor based on the functional analysis of murine IL-6Ralpha(1).Semantic proximity Read ↗

Analysis of the leukemia inhibitory factor receptor functional domains by chimeric receptors and cytokines.Semantic proximity Read ↗

Unraveling Viral Interleukin-6 Binding to gp130 and Activation of STAT-Signaling Pathways Independently of the Interleukin-6 ReceptorSemantic proximity Read ↗

Involvement of the Arg179 in the active site of human IL‐6Semantic proximity Read ↗

Identification, Cloning, and Characterization of a Novel Soluble Receptor That Binds IL-22 and Neutralizes Its ActivitySemantic proximity Read ↗

Establishment of a New Interleukin-6 (IL-6) Receptor Inhibitor Applicable to the Gene Therapy for IL-6–Dependent TumorSemantic proximity Read ↗

A Novel Small-Molecule Inhibitor Targeting the IL-6 Receptor β Subunit, Glycoprotein 130Semantic proximity Read ↗

Mapping of the leptin binding sites and design of a leptin antagonist.Semantic proximity Read ↗

Generation and characterization of a human monoclonal autoantibody that acts as a high affinity interleukin-1 alpha specific inhibitor.Semantic proximity Read ↗

Analysis of the Human Interleukin-6/Human Interleukin-6 Receptor Binding Interface at the Amino Acid Level: Proposed Mechanism of InteractionSemantic proximity Read ↗

CD6 monoclonal antibodies differ in epitope, kinetics and mechanism of action.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.