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Article

The expression analysis of mouse interleukin-6 splice variants argued against their biological relevance.

BMB reports - 1 Jan 2012

Annibalini Giosuè, Guescini Michele, Agostini Deborah, Matteis Rita De, Sestili Piero, Tibollo Pasquale, Mantuano Michela, Martinelli Chiara, Stocchi Vilberto

Abstract excerpt

Alternative splicing generates several interleukin-6 (IL-6) isoforms; for them an antagonistic activity to the wild-type IL-6 has been proposed. In this study we quantified the relative abundance of IL-6 mRNA isoforms in a panel of mouse tissues and in C2C12 cells during myoblast differentiation or after treatment with the Ca(2+) ionophore A23187, the AMP-mimetic AICAR and TNF-α. The two mouse IL-6 isoforms...

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PMID: 22281010
DOI: 10.5483/bmbrep.2012.45.1.32

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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