The expression analysis of mouse interleukin-6 splice variants argued against their biological relevance.

doi:10.5483/bmbrep.2012.45.1.32

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Article

The expression analysis of mouse interleukin-6 splice variants argued against their biological relevance.

BMB reports - 1 Jan 2012

Annibalini Giosuè, Guescini Michele, Agostini Deborah, Matteis Rita De, Sestili Piero, Tibollo Pasquale, Mantuano Michela, Martinelli Chiara, Stocchi Vilberto

Abstract excerpt

Alternative splicing generates several interleukin-6 (IL-6) isoforms; for them an antagonistic activity to the wild-type IL-6 has been proposed. In this study we quantified the relative abundance of IL-6 mRNA isoforms in a panel of mouse tissues and in C2C12 cells during myoblast differentiation or after treatment with the Ca(2+) ionophore A23187, the AMP-mimetic AICAR and TNF-α. The two mouse IL-6 isoforms...

Topics

Alternative Splicing
Animals
Cells, Cultured
Female
Genetic Variation
HeLa Cells
Humans
Interleukin-6
Male
Mice
Mice, Inbred BALB C
Rats
Rats, Sprague-Dawley
Reverse Transcriptase Polymerase Chain Reaction

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Open in PubMed

Identifiers

PMID: 22281010
DOI: 10.5483/bmbrep.2012.45.1.32

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