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Article

Interleukin 8 dimerization as a mechanism for regulation of neutrophil adherence-dependent oxidant production.

Shock (Augusta, Ga.) - 1 Apr 2005

Williams Mark A, Cave Cindy M, Quaid Gina, Robinson Chad, Daly Thomas J, Witt Dan, Lentsch Alex B, Solomkin Joseph S

Abstract excerpt

Interleukin 8 (IL-8), a member of the CXC subfamily of chemoattractant cytokines, induces a range of functional responses in human neutrophils via its interactions with two high-affinity cell-surface receptors, CXCR1 and CXCR2. Like other CXC chemokines, IL-8 forms homodimers at physiologic concentrations. Monomers and dimers bind to CXC receptors with high affinity and induce various functions. Binding to...

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Source

Identifiers

PMID: 15803062
DOI: 10.1097/01.shk.0000158140.58335.54

Genes

CXCR1
CXCR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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