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Article

Efavirenz induces CYP2B6-mediated hydroxylation of bupropion in healthy subjects.

Journal of acquired immune deficiency syndromes (1999) - 15 Dec 2008

Robertson Sarah M, Maldarelli Frank, Natarajan Ven, Formentini Elizabeth, Alfaro Raul M, Penzak Scott R

Abstract excerpt

OBJECTIVE: To characterize the effect of efavirenz on bupropion hydroxylation as a marker of cytochrome P450 (CYP) 2B6 activity in healthy subjects. METHODS: Thirteen subjects received a single oral dose of bupropion SR 150 mg before and after 2 weeks of efavirenz administration for comparison of bupropion and hydroxybupropion pharmacokinetics. Efavirenz plasma concentrations were also assessed. Subjects were...

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Identifiers

PMID: 18989234
DOI: 10.1097/QAI.0b013e318183a425
PMCID: PMC9036313

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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