Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Stereoselective bupropion hydroxylation as an in vivo phenotypic probe for cytochrome P4502B6 (CYP2B6) activity.

Journal of clinical pharmacology - 1 Apr 2008

Kharasch Evan D, Mitchell Darain, Coles Rebecka

Abstract excerpt

The clearance of racemic bupropion, metabolized selectively by CYP2B6 in vitro, has been used clinically to phenotype CYP2B6 activity, polymorphisms, and drug interactions but has known limitations. Bupropion hydroxylation by CYP2B6 is stereoselective. This investigation assessed the stereoselect...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antidepressive Agents, Second-Generation
Share to Bupropion
Share to Cross-Over Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2B6

Share to Half-Life

Share to Hydroxylation

Share to Oxidoreductases, N-Demethylating

Share to Stereoisomerism

Source

Identifiers

PMID: 18287571
DOI: 10.1177/0091270008314254

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18287571-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Stereoselective bupropion hydroxylation as an in vivo phenotypic probe for cytochrome P4502B6 (CYP2B6) activity.PMID 18287571Read ↗

Common Polymorphisms of CYP2B6 Influence Stereoselective Bupropion Disposition.Semantic proximity Read ↗

Stereoselective Bupropion Hydroxylation by Cytochrome P450 CYP2B6 and Cytochrome P450 Oxidoreductase Genetic Variants.Semantic proximity Read ↗

Rapid clinical induction of bupropion hydroxylation by metamizole in healthy Chinese men.Semantic proximity Read ↗

Efavirenz induces CYP2B6-mediated hydroxylation of bupropion in healthy subjects.Semantic proximity Read ↗

Bupropion and 4-OH-bupropion pharmacokinetics in relation to genetic polymorphisms in CYP2B6.Semantic proximity Read ↗

Influence of CYP2B6 genetic variants on plasma and urine concentrations of bupropion and metabolites at steady state.Semantic proximity Read ↗

The influence of sex, ethnicity, and CYP2B6 genotype on bupropion metabolism as an index of hepatic CYP2B6 activity in humans.Semantic proximity Read ↗

Induction of cytochrome P450 2B6 activity by the herbal medicine baicalin as measured by bupropion hydroxylation.Semantic proximity Read ↗

Association of CYP2B6 genetic polymorphisms with bupropion and hydroxybupropion exposure: A systematic review and meta-analysis.Semantic proximity Read ↗

Pharmacogenetic determinants of interindividual variability in bupropion hydroxylation by cytochrome P450 2B6 in human liver microsomes.Semantic proximity Read ↗

Use of enantiomeric bupropion and hydroxybupropion to assess CYP2B6 activity in glomerular kidney diseases.Semantic proximity Read ↗

The P450 oxidoreductase (POR) rs2868177 and cytochrome P450 (CYP) 2B6*6 polymorphisms contribute to the interindividual variability in human CYP2B6 activity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.