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Article

Impact of CYP2B6 polymorphism on hepatic efavirenz metabolism in vitro.

Pharmacogenomics - 1 Jun 2007

Desta Zeruesenay, Saussele Tanja, Ward Bryan, Blievernicht Julia, Li Lang, Klein Kathrin, Flockhart David A, Zanger Ulrich M

Abstract excerpt

OBJECTIVES: To determine the influence of cytochrome P450 2B6 (CYP2B6) genotype on the rate of oxidative efavirenz metabolism in human liver microsomes. MATERIALS & METHODS: Formation rates of 8-hydroxyefavirenz, 7-hydroxyefavirenz and 8,14-dihydroxyefavirenz were determined in vitro with efavirenz as a substrate (10 microM) in a large panel of human liver microsomes (n = 87) that were genotyped for variants of...

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PMID: 17559344
DOI: 10.2217/14622416.8.6.547

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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