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Article

Stereoselective Bupropion Hydroxylation by Cytochrome P450 CYP2B6 and Cytochrome P450 Oxidoreductase Genetic Variants.

Drug metabolism and disposition: the biological fate of chemicals - 1 Jun 2020

Wang Pan-Fen, Neiner Alicia, Kharasch Evan D

Abstract excerpt

Bioactivation of the antidepressant and smoking cessation drug bupropion is catalyzed predominantly by CYP2B6. The metabolite hydroxybupropion derived from t-butylhydroxylation is considered to contribute to the antidepressant and smoking-cessation effects of the parent drug. Bupropion hydroxylation is the canonical in vitro and in vivo probe for CYP2B6 activity. P450 also requires obligate partnership with P450...

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Identifiers

PMID: 32238417
DOI: 10.1124/dmd.119.090407
PMCID: PMC7228493

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