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Article

COMT (Val(158/108)Met) genotype moderates the impact of antipsychotic medication on verbal IQ in twins with schizophrenia.

Psychiatric genetics - 1 Apr 2011

Rebollo-Mesa Irene, Picchioni Marco, Shaikh Madiha, Bramon Elvira, Murray Robin, Toulopoulou Timothea

Abstract excerpt

OBJECTIVES: In this study, we aimed to assess the moderating effects of the catechol-O-methyl transferase (COMT) (Val(158/108)Met) genotype on antipsychotic medication-induced changes in the cognitive performance of patients with chronic schizophrenia. METHODS: The sample consisted of 85 monozygotic and 53 dizygotic twin pairs, of varying concordance for schizophrenia, and healthy control twins. Cognitive ability...

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Source

Identifiers

PMID: 21233783
DOI: 10.1097/YPG.0b013e32834371a7

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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