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COMT val108/158met genotype, cognitive function, and cognitive improvement with clozapine in schizophrenia.

Schizophrenia research - 1 Feb 2007

Woodward Neil D, Jayathilake Karu, Meltzer Herbert Y

Abstract excerpt

Preliminary evidence suggests that a single nucleotide polymorphism (SNP), the val108/158met SNP, within the gene that codes for catechol-O-methyltransferase (COMT), a key enzyme involved in regulating dopamine (DA) transmission within the prefrontal cortex (PFC), is related to cognitive function in schizophrenia and cognitive improvement with atypical antipsychotic drugs (APDs). Specifically, several studies...

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Antipsychotic Agents
Catechol O-Methyltransferase
Clozapine
Cognition Disorders
Memory, Short-Term

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PMID: 17123785
DOI: 10.1016/j.schres.2006.10.002

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COMT

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COMT val108/158met genotype, cognitive function, and cognitive improvement with clozapine in schizophrenia.PMID 17123785Read ↗

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Catechol-O-methyltransferase polymorphisms and some implications for cognitive therapeutics.Semantic proximity Read ↗

Catechol O-methyltransferase variants and cognitive performance in schizophrenia and bipolar disorder versus controls.Semantic proximity Read ↗

COMT (Val(158/108)Met) genotype moderates the impact of antipsychotic medication on verbal IQ in twins with schizophrenia.Semantic proximity Read ↗

Neurocognitive correlates of the COMT Val(158)Met polymorphism in chronic schizophrenia.Semantic proximity Read ↗

Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia.Semantic proximity Read ↗

Meta-analysis of the cognitive effects of the catechol-O-methyltransferase gene Val158/108Met polymorphism.Semantic proximity Read ↗

Effects of the catechol-O-methyltransferase Val158Met polymorphism on executive function: a meta-analysis of the Wisconsin Card Sort Test in schizophrenia and healthy controls.Semantic proximity Read ↗

MTHFR 677C --> T genotype disrupts prefrontal function in schizophrenia through an interaction with COMT 158Val --> Met.Semantic proximity Read ↗

Association Between the COMT Val158Met Polymorphism and Antipsychotic Efficacy in Schizophrenia: An Updated Meta-Analysis.Semantic proximity Read ↗

Effect of COMT val158met genotype on cognition and personality.Semantic proximity Read ↗

Catechol-O-methyltransferase Val158Met polymorphism in schizophrenia: associations with cognitive and motor impairment.Semantic proximity Read ↗

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