Article
Neurocognitive correlates of the COMT Val(158)Met polymorphism in chronic schizophrenia.
Biological psychiatry - 1 Oct 2002
Bilder Robert M, Volavka Jan, Czobor Pál, Malhotra Anil K, Kennedy James L, Ni Xingqun, Goldman Robert S, Hoptman Matthew J, Sheitman Brian, Lindenmayer Jean-Pierre, Citrome Leslie, McEvoy Joseph P, Kunz Michal, Chakos Miranda, Cooper Thomas B, Lieberman Jeffrey A
Abstract excerpt
BACKGROUND: Neurocognitive deficits are recognized as a cardinal feature of schizophrenia, but the determinants of these deficits remain unknown. Recent reports have suggested that a functional polymorphism, Val(158)Met in exon III of the catechol-O-methyltransferase gene, shares approximately 4% variance with performance on the Wisconsin Card Sorting Test. These findings led to suggestions that the...
Topics
Join the communities discussing this publication.