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Article

Interactive effects of COMT Val108/158Met and MTHFR C677T on executive function in schizophrenia.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Sept 2008

Roffman Joshua L, Weiss Anthony P, Deckersbach Thilo, Freudenreich Oliver, Henderson David C, Wong Donna H, Halsted Charles H, Goff Donald C

Abstract excerpt

Schizophrenia is characterized by heritable deficits in executive function. Two common, functional polymorphisms, catechol-O-methyltransferase (COMT) Val108/158Met and methylenetetrahydrofolate reductase (MTHFR) C677T, have separately been associated with executive function performance in schizophrenia. Given the closely related biochemistry of MTHFR and COMT, it is plausible that the T and Val alleles act...

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Source

Identifiers

PMID: 18186041
DOI: 10.1002/ajmg.b.30684

Genes

COMT
MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Interactive effects of COMT Val108/158Met and MTHFR C677T on executive function in schizophrenia.PMID 18186041Read ↗

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