Article
High-fidelity correction of genomic uracil by human mismatch repair activities.
BMC molecular biology - 27 Oct 2008
Larson Erik D, Bednarski David W, Maizels Nancy
Abstract excerpt
BACKGROUND: Deamination of cytosine to produce uracil is a common and potentially mutagenic lesion in genomic DNA. U*G mismatches occur spontaneously throughout the genome, where they are repaired by factors associated with the base excision repair pathway. U*G mismatches are also the initiating lesion in immunoglobulin gene diversification, where they undergo mutagenic processing by redundant pathways, one...
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