Article
Hijacked DNA repair proteins and unchained DNA polymerases.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 12 Mar 2009
Saribasak Huseyin, Rajagopal Deepa, Maul Robert W, Gearhart Patricia J
Abstract excerpt
Somatic hypermutation of immunoglobulin (Ig) genes occurs at a frequency that is a million times greater than the mutation in other genes. Mutations occur in variable genes to increase antibody affinity, and in switch regions before constant genes to cause switching from IgM to IgG. Hypermutation is initiated in activated B cells when the activation-induced deaminase protein deaminates cytosine in DNA to uracil....
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