DNA Repair in mammalian cells: Mismatched repair: variations on a theme.

doi:10.1007/s00018-009-8739-9

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Article

DNA Repair in mammalian cells: Mismatched repair: variations on a theme.

Cellular and molecular life sciences : CMLS - 1 Mar 2009

Kunz C, Saito Y, Schär P

Abstract excerpt

Complementary base pairing underlies the genetic template function of the DNA double helix. Therefore, to assure faithful DNA transactions, cells must adhere to a strict application of the Watson-Crick base pairing principle.Yet, mispairing does arise in DNA, most frequently as a result of DNA polymerase errors or base damage. These mismatches need be rectified to avoid mutation. Sometimes, however, mispairing is...

Topics

Animals
Base Pairing
DNA Damage
DNA Mismatch Repair
DNA-Directed DNA Polymerase
Humans
Mutagenesis
Mutation
Templates, Genetic

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Identifiers

PMID: 19153655
DOI: 10.1007/s00018-009-8739-9
PMCID: PMC11131451

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