Mismatch repair in replication fidelity, genetic recombination, and cancer biology.

doi:10.1146/annurev.bi.65.070196.000533

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Article

Mismatch repair in replication fidelity, genetic recombination, and cancer biology.

Annual review of biochemistry - 1 Jan 1996

Modrich P, Lahue R

Abstract excerpt

Mismatch repair stabilizes the cellular genome by correcting DNA replication errors and by blocking recombination events between divergent DNA sequences. The reaction responsible for strand-specific correction of mispaired bases has been highly conserved during evolution, and homologs of bacteria...

Topics

Animals
DNA Repair
DNA Replication
Escherichia coli
Humans
Mitosis
Neoplasms
Nucleic Acid Heteroduplexes
Phenotype
Recombination, Genetic

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