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Article

The concerted action of Msh2 and UNG stimulates somatic hypermutation at A . T base pairs.

Molecular and cellular biology - 1 Sept 2009

Frieder Darina, Larijani Mani, Collins Cathy, Shulman Marc, Martin Alberto

Abstract excerpt

Mismatch repair plays an essential role in reducing the cellular mutation load. Paradoxically, proteins in this pathway produce A . T mutations during the somatic hypermutation of immunoglobulin genes. Although recent evidence implicates the translesional DNA polymerase eta in producing these mutations, it is unknown how this or other translesional polymerases are recruited to immunoglobulin genes, since these...

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Share to AICDA (Activation-Induced Cytidine Deaminase)
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 19596785
DOI: 10.1128/MCB.00647-09
PMCID: PMC2738296

Genes

UNG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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