Article
Association of the GNAS locus with severe malaria.
Human genetics - 1 Dec 2008
Auburn Sarah, Diakite Mahamadou, Fry Andrew E, Ghansah Anita, Campino Susana, Richardson Anna, Jallow Muminatou, Sisay-Joof Fatou, Pinder Margaret, Griffiths Michael J, Peshu Norbert, Williams Thomas N, Marsh Kevin, Molyneux Malcolm E, Taylor Terrie E, Koram Kwadwo A, Oduro Abraham R, Rogers William O, Rockett Kirk A, Haldar Kasturi, Kwiatkowski Dominic P
Abstract excerpt
Functional studies have demonstrated an interaction between the stimulatory G protein alpha subunit (G-alpha-s) and the malaria parasite at a cellular level. Obstruction of signal transduction via the erythrocyte G-alpha-s subunit reduced invasion by Plasmodium falciparum parasites. We sought to determine whether this signal pathway had an impact at the disease level by testing polymorphisms in the gene encoding...
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