Article
Genome-wide linkage analysis of malaria infection intensity and mild disease.
PLoS genetics - 23 Mar 2007
Timmann Christian, Evans Jennifer A, König Inke R, Kleensang André, Rüschendorf Franz, Lenzen Julia, Sievertsen Jürgen, Becker Christian, Enuameh Yeetey, Kwakye Kingsley Osei, Opoku Ernest, Browne Edmund N L, Ziegler Andreas, Nürnberg Peter, Horstmann Rolf D
Abstract excerpt
Although balancing selection with the sickle-cell trait and other red blood cell disorders has emphasized the interaction between malaria and human genetics, no systematic approach has so far been undertaken towards a comprehensive search for human genome variants influencing malaria. By screening 2,551 families in rural Ghana, West Africa, 108 nuclear families were identified who were exposed to hyperendemic...
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