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Article

Epistasis between the haptoglobin common variant and α+thalassemia influences risk of severe malaria in Kenyan children.

Blood - 27 Mar 2014

Atkinson Sarah H, Uyoga Sophie M, Nyatichi Emily, Macharia Alex W, Nyutu Gideon, Ndila Carolyne, Kwiatkowski Dominic P, Rockett Kirk A, Williams Thomas N

Abstract excerpt

Haptoglobin (Hp) scavenges free hemoglobin following malaria-induced hemolysis. Few studies have investigated the relationship between the common Hp variants and the risk of severe malaria, and their results are inconclusive. We conducted a case-control study of 996 children with severe Plasmodium falciparum malaria and 1220 community controls and genotyped for Hp, hemoglobin (Hb) S heterozygotes, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24478401
DOI: 10.1182/blood-2013-10-533489
PMCID: PMC3968387

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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