Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tumor necrosis factor and lymphotoxin-alpha polymorphisms and severe malaria in African populations.

The Journal of infectious diseases - 15 Feb 2009

Clark Taane G, Diakite Mahamadou, Auburn Sarah, Campino Susana, Fry Andrew E, Green Angela, Richardson Anna, Small Kerrin, Teo Yik Y, Wilson Jonathan, Jallow Muminatou, Sisay-Joof Fatou, Pinder Margaret, Griffiths Michael J, Peshu Norbert, Williams Thomas N, Marsh Kevin, Molyneux Malcolm E, Taylor Terrie E, Rockett Kirk A, Kwiatkowski Dominic P

Abstract excerpt

The tumor necrosis factor gene (TNF) and lymphotoxin-alpha gene (LTA) have long attracted attention as candidate genes for susceptibility traits for malaria, and several of their polymorphisms have been found to be associated with severe malaria (SM) phenotypes. In a large study involving >10,000 individuals and encompassing 3 African populations, we found evidence to support the reported associations between the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gambia
Share to Kenya

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Linkage Disequilibrium

Share to Lymphotoxin-alpha

Share to Malaria, Falciparum

Share to Malawi

Share to Oligonucleotide Array Sequence Analysis

Share to Tumor Necrosis Factor-alpha

Source

Open in PubMed Open full text

Identifiers

PMID: 19281305
DOI: 10.1086/596320
PMCID: PMC2742199

Genes

TNF
LTA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tumor necrosis factor and lymphotoxin-alpha polymorphisms and severe malaria in African populations.PMID 19281305Read ↗

A study of the TNF/LTA/LTB locus and susceptibility to severe malaria in highland papuan children and adults.Semantic proximity Read ↗

A genetic association study in the Gambia using tagging polymorphisms in the major histocompatibility complex class III region implicates a HLA-B associated transcript 2 polymorphism in severe malaria susceptibility.Semantic proximity Read ↗

Family-based association of a low producing lymphotoxin-alpha allele with reduced Plasmodium falciparum parasitemia.Semantic proximity Read ↗

Severe malarial anemia and cerebral malaria are associated with different tumor necrosis factor promoter alleles.Semantic proximity Read ↗

TNF-α promoter variant (G-308A) is associated with susceptibility to P. falciparum infection and severe malaria: a meta-analysis and trial sequential analysis.Semantic proximity Read ↗

Tumor necrosis factor-α (TNF-α) -308G >a promoter polymorphism (rs1800629) promotes Asians in susceptibility to Plasmodium falciparum severe malaria: A meta-analysis.Semantic proximity Read ↗

TNF-α 238 Alleles Polymorphism and its Association With TNF-α Levels in the Severe Malaria Anemia Among Sudanese ChildrenSemantic proximity Read ↗

Variation in human genes encoding adhesion and proinflammatory molecules are associated with severe malaria in the Vietnamese.Semantic proximity Read ↗

TNF as a malaria candidate gene: polymorphism-screening and family-based association analysis of mild malaria attack and parasitemia in Burkina Faso.Semantic proximity Read ↗

Age-related susceptibility to severe malaria associated with galectin-2 in highland Papuans.Semantic proximity Read ↗

Tumour necrosis factor alpha promoter polymorphism, TNF-238 is associated with severe clinical outcome of falciparum malaria in Ibadan southwest Nigeria.Semantic proximity Read ↗

Tumor necrosis factor SNP haplotypes are associated with iron deficiency anemia in West African children.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.