Article
Effects of natural selection and gene conversion on the evolution of human glycophorins coding for MNS blood polymorphisms in malaria-endemic African populations.
American journal of human genetics - 10 Jun 2011
Ko Wen-Ya, Kaercher Kristin A, Giombini Emanuela, Marcatili Paolo, Froment Alain, Ibrahim Muntaser, Lema Godfrey, Nyambo Thomas B, Omar Sabah A, Wambebe Charles, Ranciaro Alessia, Hirbo Jibril B, Tishkoff Sarah A
Abstract excerpt
Malaria has been a very strong selection pressure in recent human evolution, particularly in Africa. Of the one million deaths per year due to malaria, more than 90% are in sub-Saharan Africa, a region with high levels of genetic variation and population substructure. However, there have been few studies of nucleotide variation at genetic loci that are relevant to malaria susceptibility across geographically and...
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