Article
Age-related susceptibility to severe malaria associated with galectin-2 in highland Papuans.
The Journal of infectious diseases - 1 Jul 2010
Randall Louise M, Kenangalem Enny, Lampah Daniel A, Tjitra Emiliana, Mwaikambo Esther D, Handojo Tjandra, Piera Kim A, Zhao Zhen Zhen, de Labastida Rivera Fabian, Zhou Yonghong, McSweeney Karli M, Le Lien, Amante Fiona H, Haque Ashraful, Stanley Amanda C, Woodberry Tonia, Salwati Ervi, Granger Donald L, Hobbs Maurine R, Price Ric N, Weinberg J Brice, Montgomery Grant W, Anstey Nicholas M, Engwerda Christian R
Abstract excerpt
BACKGROUND: Age and host genetics are important determinants of malaria severity. Lymphotoxin-alpha (LTalpha) has been associated with the development of cerebral malaria (CM) and other severe malaria (SM) syndromes. Mutations in genes regulating LTalpha production contribute to other acute vascu...
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