Article
Categorical complexities of Plasmodium falciparum malaria in individuals is associated with genetic variations in ADORA2A and GRK5 genes.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Aug 2015
Gupta Himanshu, Jain Aditya, Saadi Abdul Vahab, Vasudevan Thanvanthri G, Hande Manjunath H, D'Souza Sydney C, Ghosh Susanta K, Umakanth Shashikiran, Satyamoorthy Kapaettu
Abstract excerpt
In the erythrocytes, malaria parasite entry and infection is mediated through complex membrane sorting and signaling processes. We investigated the effects of single-locus and multilocus interactions to test the hypothesis that the members of the GPCR family genes, adenosine A2a receptor (ADORA2A) and G-protein coupled receptor kinase5 (GRK5), may contribute to the pathogenesis of malaria caused by Plasmodium...
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