Article
Expression profiling of chicken DT40 lymphoma cells indicates clonal selection of knockout and gene reconstituted cells.
Biochemical and biophysical research communications - 12 Dec 2008
Nawaz Hossain M, Blomberg K Emelie M, Lindvall Jessica M, Kurosaki Tomohiro, Smith C I Edvard
Abstract excerpt
The DT40 cell-line has been extensively used to create deletion mutants, one of which lacks Bruton's tyrosine kinase (Btk). Btk is a cytoplasmic tyrosine kinase important for B-lymphocyte maturation. It was previously shown that there are differences in gene expression between wild-type and Btk-deficient animals. Global gene expression profiling of the avian B-lymphoma DT40 cell-line was used as a model to...
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