Article
[Molecular dissection by gene targeting in the chicken B cell line DT40].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica - 1 May 1999
Okada H, Kurosaki T
Abstract excerpt
The gene-targeting experiment is a powerful tool for clarifying the functions of each gene product. For instance, establishment of a gene-knockout mouse, undoubtedly, contributes to our understanding of the functions of each gene in vivo. However, assuming that the gene product is expressed in various lineage cells, the phenotype in this knockout mouse exhibits a mixture of defects in various lineage cells. Thus,...
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