Article
Use of gene knockouts in cultured cells to study apoptosis.
Methods (San Diego, Calif.) - 1 Apr 1999
Lahti J M
Abstract excerpt
The avian DT40 cell system represents a novel method to generate loss of function mutations in vertebrate cells. These chicken B lymphoma cells undergo homologous recombination at very high frequencies and can thus be used to "knock out" genes believed to function in apoptotic processes. The knockout cells can then be used to determine how the cell death process is modulated after induction of apoptosis and to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.