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Article

Reverse genetic studies of homologous DNA recombination using the chicken B-lymphocyte line, DT40.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 29 Jan 2001

Sonoda E, Morrison C, Yamashita Y M, Takata M, Takeda S

Abstract excerpt

DT40 is an avian leucosis virus-transformed chicken B-lymphocyte line which exhibits high ratios of targeted to random integration of transfected DNA constructs. This efficient targeted integration may be related to the ongoing diversification of the variable segment of the immunoglobulin gene through homologous DNA recombination-controlled gene conversion. DT40s are a convenient model system for making...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 11205323
DOI: 10.1098/rstb.2000.0755
PMCID: PMC1087698

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Reverse genetic studies of homologous DNA recombination using the chicken B-lymphocyte line, DT40.PMID 11205323Read ↗

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The genome of the chicken DT40 bursal lymphoma cell line.Semantic proximity Read ↗

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The DT40 web site: sampling and connecting the genes of a B cell line.Semantic proximity Read ↗

Gene function analysis using the chicken B-cell line DT40.Semantic proximity Read ↗

Reduced X-ray resistance and homologous recombination frequencies in a RAD54-/- mutant of the chicken DT40 cell line.Semantic proximity Read ↗

Immunoglobulin gene conversion: insights from bursal B cells and the DT40 cell line.Semantic proximity Read ↗

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