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Article

DT40 mutants: a model to study transcriptional regulation of B cell development and function.

Sub-cellular biochemistry - 1 Jan 2006

Alinikula Jukka, Lassila Olli, Nera Kalle-Pekka

Abstract excerpt

A key issue in understanding the hematopoietic system and B cell biology is to define the function of transcription factors. B lymphocyte development and function is controlled by a hierarchy of transcription factors including PU.1, Ikaros, E2A, EBF, Pax5 and Aiolos. Mouse knockout models provide information about the developmental and physiological importance of the disrupted gene. However, an early block in the...

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PMID: 17623906
DOI: 10.1007/978-1-4020-4896-8_11

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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DT40 mutants: a model to study transcriptional regulation of B cell development and function.PMID 17623906Read ↗

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