An approximately half set of histone genes is enough for cell proliferation and a lack of several histone variants causes protein pattern changes in the DT40 chicken B cell line.

Abstract excerpt

Of the 44 chicken histone genes, 39 are located in a major histone gene cluster of 110 kb, the others residing in four separate regions. The 42 sequenced genes encode six H1 variants, three H2A variants, four H2B variants, two H3 variants, and one histone H4. To clarify the influence on cell functions of simultaneous deletion of an approximately half set of the genes and some of the variants, we generated...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cell Division
• Share to Cell Line