Article
One allele of the major histone gene cluster is enough for cell proliferation of the DT40 chicken B cell line.
Biochimica et biophysica acta - 1 Nov 1997
Takami Y, Nakayama T
Abstract excerpt
Thirty-nine of the 44 chicken histone genes are located in a major histone gene cluster of 110 kb, the others residing in four separate regions. We generated a heterozygous chicken DT40 mutant, 1/2 delta110 kb, devoid of one allele of the cluster, using gene targeting techniques. Analyses of the mutant revealed that the growth rate of DT40 cells was unchanged even in the absence of one allele of the cluster....
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