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Intrinsic properties of the two replicative DNA polymerases of Pyrococcus abyssi in replicating abasic sites: possible role in DNA damage tolerance?

Molecular microbiology - 1 Nov 2008

Palud Adeline, Villani Giuseppe, L'Haridon Stéphane, Querellou Joël, Raffin Jean-Paul, Henneke Ghislaine

Abstract excerpt

Spontaneous and induced abasic sites in hyperthermophiles DNA have long been suspected to occur at high frequency. Here, Pyrococcus abyssi was used as an attractive model to analyse the impact of such lesions onto the maintenance of genome integrity. We demonstrated that endogenous AP sites persist at a slightly higher level in P. abyssi genome compared with Escherichia coli. Then, the two replicative DNA...

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PMID: 18826407
DOI: 10.1111/j.1365-2958.2008.06446.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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