Article
Characterization of family D DNA polymerase from Thermococcus sp. 9°N.
Extremophiles : life under extreme conditions - 1 Jul 2014
Greenough Lucia, Menin Julie F, Desai Nirav S, Kelman Zvi, Gardner Andrew F
Abstract excerpt
Accurate DNA replication is essential for maintenance of every genome. All archaeal genomes except Crenarchaea, encode for a member of Family B (polB) and Family D (polD) DNA polymerases. Gene deletion studies in Thermococcus kodakaraensis and Methanococcus maripaludis show that polD is the only essential DNA polymerase in these organisms. Thus, polD may be the primary replicative DNA polymerase for both leading...
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