Endogenous lesions, S-phase-independent spontaneous mutations, and evolutionary strategies for base excision repair.

doi:10.1016/s0027-5107(98)00051-7

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Article

Endogenous lesions, S-phase-independent spontaneous mutations, and evolutionary strategies for base excision repair.

Mutation research - 25 May 1998

Holmquist G P

Abstract excerpt

We calculate from published levels of endogenous base lesions that our cells constantly generate and excise during base excision repair (BER) about one million lesions per day. Repair glycosylases may also non-specifically excise an additional number of undamaged bases. The resulting abasic sites...

Topics

Animals
DNA Glycosylases
DNA Repair
Evolution, Molecular
Humans
Mutagenesis
Mutation
N-Glycosyl Hydrolases
S Phase
Substrate Specificity

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