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Article

Endogenous lesions, S-phase-independent spontaneous mutations, and evolutionary strategies for base excision repair.

Mutation research - 25 May 1998

Holmquist G P

Abstract excerpt

We calculate from published levels of endogenous base lesions that our cells constantly generate and excise during base excision repair (BER) about one million lesions per day. Repair glycosylases may also non-specifically excise an additional number of undamaged bases. The resulting abasic sites are repaired daily by BER. The fidelity of polymerase-beta is 2.4x10(-5) and one must postulate additional fidelity...

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Identifiers

PMID: 9685584
DOI: 10.1016/s0027-5107(98)00051-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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