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Article

DNA polymerase from temperate phage Bam35 is endowed with processive polymerization and abasic sites translesion synthesis capacity.

Proceedings of the National Academy of Sciences of the United States of America - 7 Jul 2015

Berjón-Otero Mónica, Villar Laurentino, de Vega Miguel, Salas Margarita, Redrejo-Rodríguez Modesto

Abstract excerpt

DNA polymerases (DNAPs) responsible for genome replication are highly faithful enzymes that nonetheless cannot deal with damaged DNA. In contrast, translesion synthesis (TLS) DNAPs are suitable for replicating modified template bases, although resulting in very low-fidelity products. Here we report the biochemical characterization of the temperate bacteriophage Bam35 DNA polymerase (B35DNAP), which belongs to the...

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Identifiers

PMID: 26100910
DOI: 10.1073/pnas.1510280112
PMCID: PMC4500267

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