Article
Error-prone replication for better or worse.
Trends in microbiology - 1 Jun 2004
Tippin Brigette, Pham Phuong, Goodman Myron F
Abstract excerpt
Precise genome duplication requires accurate copying by DNA polymerases and the elimination of occasional mistakes by proofreading exonucleases and mismatch repair enzymes. The commonly held belief that 'if something is worth doing, then it's worth doing well' normally applies to DNA replication and repair, however, there are exceptions. This review describes elements that are crucial to cell fitness, evolution...
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