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Article

Structural basis of transcriptional stalling and bypass of abasic DNA lesion by RNA polymerase II.

Proceedings of the National Academy of Sciences of the United States of America - 13 Mar 2018

Wang Wei, Walmacq Celine, Chong Jenny, Kashlev Mikhail, Wang Dong

Abstract excerpt

Abasic sites are among the most abundant DNA lesions and interfere with DNA replication and transcription, but the mechanism of their action on transcription remains unknown. Here we applied a combined structural and biochemical approach for a comprehensive investigation of how RNA polymerase II (Pol II) processes an abasic site, leading to slow bypass of lesion. Encounter of Pol II with an abasic site involves...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29487211
DOI: 10.1073/pnas.1722050115
PMCID: PMC5856558

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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