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Article

The mechanistic architecture of thermostable Pyrococcus furiosus family B DNA polymerase motif A and its interaction with the dNTP substrate.

Biochemistry - 1 Dec 2009

Kennedy Edward M, Hergott Christopher, Dewhurst Stephen, Kim Baek

Abstract excerpt

Thermostable DNA polymerases isolated from archaeal organisms have not been completely characterized kinetically and require further study if we are to understand both their dNTP binding mechanism and their role within the organism. Here, we demonstrate that the thermostable family B DNA polymerase from Pyrococcus furiosus (Pfu Pol) contains sensitive determinants of both dNTP binding and replicational fidelity...

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Identifiers

PMID: 19817489
DOI: 10.1021/bi9010122
PMCID: PMC3097049

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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