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Article

A read-ahead function in archaeal DNA polymerases detects promutagenic template-strand uracil.

Proceedings of the National Academy of Sciences of the United States of America - 3 Aug 1999

Greagg M A, Fogg M J, Panayotou G, Evans S J, Connolly B A, Pearl L H

Abstract excerpt

Deamination of cytosine to uracil is the most common promutagenic change in DNA, and it is greatly increased at the elevated growth temperatures of hyperthermophilic archaea. If not repaired to cytosine prior to replication, uracil in a template strand directs incorporation of adenine, generating...

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Identifiers

PMID: 10430892
DOI: 10.1073/pnas.96.16.9045
PMCID: PMC17729

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-10430892-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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