Article

Hypertension-mediated cardiac fibrosis is a mechanical process initiated by smooth muscle cells

2026-06-01

Abstract excerpt

Hypertension represents the most prevalent chronic cardiovascular condition, typically culminating in pathological cardiac remodeling characterized by hypertrophy and extensive fibrosis. Although the cellular phenotypes associated with these changes are well-documented, the precise mechanisms by which hypertensive stress is sensed and transduced into a fibrotic program remain poorly defined. To elucidate these mec...

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Literature Corpus work: eed8950a-3e7e-5fa4-86ae-9a0d4fa2f3c6
DOI: 10.64898/2026.05.28.728606

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