Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of functionally important amino acid residues in the mitochondria targeting sequence of hepatitis B virus X protein.

Virology - 10 Nov 2008

Li Sai Kam, Ho Sai Fan, Tsui Kwok Wing, Fung Kwok Pui, Waye M Y Mary

Abstract excerpt

Chronic hepatitis B virus (HBV) infection has been strongly associated with hepatocellular carcinoma (HCC) and the X protein (HBx) is thought to mediate the cellular changes associated with carcinogenesis. Recently, isolation of the hepatitis B virus integrants from HCC tissue by others have established the fact that the X gene is often truncated at its C-terminus. Expression of the GFP fusion proteins of HBx and...

Topics

Amino Acids
Carcinoma, Hepatocellular
Cell Line
Gene Expression Regulation, Viral
Green Fluorescent Proteins
Hepatitis B virus
Humans
Mitochondria
Mutation
Protein Transport
Trans-Activators

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Viral Regulatory and Accessory Proteins

Source

Identifiers

PMID: 18805561
DOI: 10.1016/j.virol.2008.07.037

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-18805561-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of functionally important amino acid residues in the mitochondria targeting sequence of hepatitis B virus X protein.PMID 18805561Read ↗

An internal segment (residues 58-119) of the hepatitis B virus X protein is sufficient to activate MAP kinase pathways in mouse liver.Semantic proximity Read ↗

Two-codon insertion mutations of the HBx define two separate regions necessary for its trans-activation function.Semantic proximity Read ↗

Accurately mapping the location of the binding site for the interaction between hepatitis B virus X protein and cytochrome c oxidase III.Semantic proximity Read ↗

A novel mutant 10Ala/Arg together with mutant 144Ser/Arg of hepatitis B virus X protein involved in hepatitis B virus-related hepatocarcinogenesis in HepG2 cell lines.Semantic proximity Read ↗

Expression and spectroscopic analysis of a mutant hepatitis B virus onco-protein HBx without cysteine residues.Semantic proximity Read ↗

Transactivating function and expression of the x gene of hepatitis B virus.Semantic proximity Read ↗

Carboxyl-terminal truncated HBx contributes to invasion and metastasis via deregulating metastasis suppressors in hepatocellular carcinoma.Semantic proximity Read ↗

Hepatitis B virus X protein is not central to the viral life cycle in vitroSemantic proximity Read ↗

Enhancement of hepatitis B virus replication by its X protein in transgenic mice.Semantic proximity Read ↗

Hepatitis B virus X protein impedes the DNA repair via its association with transcription factor, TFIIH.Semantic proximity Read ↗

Contribution of C1485T mutation in the HBx gene to human and murine hepatocarcinogenesis.Semantic proximity Read ↗

A long HBV transcript encoding pX is inefficiently exported from the nucleus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.