Hepatitis B virus X protein is not central to the viral life cycle in vitro

doi:10.1128/jvi.66.2.1223-1227.1992

Article

Hepatitis B virus X protein is not central to the viral life cycle in vitro

1 Feb 1992

Abstract excerpt

The hepatitis B x (HBx) gene is the smallest open reading frame of the hepatitis B virus (HBV) genome. It is conserved among all mammalian hepadnaviruses and is expressed during viral infection. While the HBx protein (pX) has been shown to trans-activate the transcription of a wide range of viral and cellular genes and to induce liver cancer in transgenic mice, the significance of pX for the life cycle of HBV...

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