Article
Accurately mapping the location of the binding site for the interaction between hepatitis B virus X protein and cytochrome c oxidase III.
International journal of molecular medicine - 1 Feb 2015
Li Dan, Ding Jian, Chen Zhixin, Chen Yun, Lin Na, Chen Fenglin, Wang Xiaozhong
Abstract excerpt
The hepatitis B virus (HBV) X protein (HBx) plays an important pathogenetic role in hepatocarcinoma tumorigenesis. As HBx does not have the ability to bind to double-stranded DNA (dsDNA), protein-protein interaction is crucial for HBx functions. In a previous study, we screened a novel HBx-interacting protein, the cytochrome c oxidase subunit III (COXIII). In the present study, we aimed to accurately map the...
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