Article
A novel mutant 10Ala/Arg together with mutant 144Ser/Arg of hepatitis B virus X protein involved in hepatitis B virus-related hepatocarcinogenesis in HepG2 cell lines.
Cancer letters - 28 Feb 2016
Shi Ying, Wang Junwei, Wang Yuhe, Wang Anna, Guo Hongliang, Wei Feili, Mehta Sanjay R, Espitia Stephen, Smith Davey M, Liu Longgen, Zhang Yulin, Chen Dexi
Abstract excerpt
Hepatitis B virus (HBV) infection-related hepatocellular carcinoma (HCC) represents a major health problem worldwide. HBV X (HBx) protein is the most common open reading frame that may undergo mutations, resulting in the development of HCC. This study aimed to determine specific HBx mutations tha...
Topics
- Adult
- Aged
- Apoptosis
- Carcinoma, Hepatocellular
- Cell Cycle
- Cell Proliferation
- Cell Transformation, Viral
- Cyclin-Dependent Kinase Inhibitor p21
- Female
- Genotype
- Hep G2 Cells
- Hepatitis B
- Hepatitis B virus
- Humans