Article
Contribution of C1485T mutation in the HBx gene to human and murine hepatocarcinogenesis.
Scientific reports - 5 Sept 2017
Hagiwara Satoru, Nishida Naoshi, Park Ah-Mee, Komeda Yoriaki, Sakurai Toshiharu, Watanabe Tomohiro, Kudo Masatoshi
Abstract excerpt
Although Hepatitis B virus (HBV) X gene mutations are frequently detected in HBV-related human hepatocellular carcinoma (HCC) patients, causative HBx mutations in the development of HCC have not yet been determined. We herein identified C1485T and C1653T mutations in the HBx gene as independent risk of HCC for HBV through the analysis using serum from chronic hepatitis B patients. We generated transgenic mice...
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