Article
Expression and spectroscopic analysis of a mutant hepatitis B virus onco-protein HBx without cysteine residues.
Journal of virological methods - 1 Jun 2005
Rui Edmilson, Moura Patricia Ribeiro de, Gonçalves Kaliandra de Almeida, Kobarg Jörg
Abstract excerpt
Chronic infection of the hepatitis B virus (HBV) is one of the causes leading to liver cancer. The 3.2kb genome of HBV encodes four proteins: core antigen, surface antigen, a DNA polymerase and the X protein (HBx). The biological functions of HBx are not fully understood. It has been shown that HBx is a potent trans-activator, which activates transcription of many cellular and viral promoters indirectly via...
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