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Article

Two-codon insertion mutations of the HBx define two separate regions necessary for its trans-activation function.

Virology - 1 Dec 1993

Runkel L, Fischer M, Schaller H

Abstract excerpt

A panel of mutants of the hepatitis B virus X gene (HBx) was constructed by oligonucleotide-directed insertion of two codons (Arg Pro) at 10- or 20-amino-acid intervals along the entire gene. These mutants were tested in transiently transfected HepG2 cells for their effects on HBx trans-activation of an AP1-CAT reporter plasmid. The effects of HBx mutations on the mRNA and protein stability were also determined....

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Identifiers

PMID: 8249276
DOI: 10.1006/viro.1993.1626

Genes

CAT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Two-codon insertion mutations of the HBx define two separate regions necessary for its trans-activation function.PMID 8249276Read ↗

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