Two-codon insertion mutations of the HBx define two separate regions necessary for its trans-activation function.

doi:10.1006/viro.1993.1626

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Article

Two-codon insertion mutations of the HBx define two separate regions necessary for its trans-activation function.

Virology - 1 Dec 1993

Runkel L, Fischer M, Schaller H

Abstract excerpt

A panel of mutants of the hepatitis B virus X gene (HBx) was constructed by oligonucleotide-directed insertion of two codons (Arg Pro) at 10- or 20-amino-acid intervals along the entire gene. These mutants were tested in transiently transfected HepG2 cells for their effects on HBx trans-activatio...

Topics

Amino Acid Sequence
Animals
Base Sequence
Cells, Cultured
Chloramphenicol O-Acetyltransferase
Codon
DNA Mutational Analysis
Gene Expression Regulation, Viral
Genes, Reporter
Hepatitis B Antigens
Humans
Molecular Sequence Data
Mutagenesis, Insertional
Mutation
Proto-Oncogene Proteins c-jun
RNA, Messenger
Receptors, Estrogen
Sequence Homology, Amino Acid

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Identifiers

PMID: 8249276
DOI: 10.1006/viro.1993.1626

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8249276-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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