An internal segment (residues 58-119) of the hepatitis B virus X protein is sufficient to activate MAP kinase pathways in mouse liver.

doi:10.1016/s0014-5793(01)02773-9

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Article

An internal segment (residues 58-119) of the hepatitis B virus X protein is sufficient to activate MAP kinase pathways in mouse liver.

FEBS letters - 24 Aug 2001

Nijhara R, Jana S S, Goswami S K, Kumar V, Sarkar D P

Abstract excerpt

The human hepatitis B virus X protein (HBx) is known as a dual-specificity transactivator stimulating the transcriptional machinery in the nucleus and signal transduction pathways in the cytoplasm. HBx-induced activation of mitogen-activated protein kinase (MAPK) signaling cascades is considered to play an important role in hepatitis B virus-mediated hepatocarcinogenesis. Herein, we have identified the regions of...

Topics

Animals
Base Sequence
Blotting, Western
DNA Primers
Enzyme Activation
Liver
MAP Kinase Signaling System
Mice
Mutation
Phosphorylation
Signal Transduction
Trans-Activators
Transcription Factor AP-1
Viral Regulatory and Accessory Proteins

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Open in PubMed

Identifiers

PMID: 11522297
DOI: 10.1016/s0014-5793(01)02773-9

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