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Article

Hepatitis B virus X protein impedes the DNA repair via its association with transcription factor, TFIIH.

BMC microbiology - 4 Mar 2011

Qadri Ishtiaq, Fatima Kaneez, AbdeL-Hafiz Hany

Abstract excerpt

BACKGROUND: Hepatitis B virus (HBV) infections play an important role in the development of hepatocellular carcinoma (HCC). HBV X protein (HBx) is a multifunctional protein that can modulate various cellular processes and plays a crucial role in the pathogenesis of HCC. HBx is known to interact with DNA helicase components of TFIIH, a basal transcriptional factor and an integral component of DNA excision repair....

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Identifiers

PMID: 21375739
DOI: 10.1186/1471-2180-11-48
PMCID: PMC3060106

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