Article
Hepatitis B virus X protein impedes the DNA repair via its association with transcription factor, TFIIH.
BMC microbiology - 4 Mar 2011
Qadri Ishtiaq, Fatima Kaneez, AbdeL-Hafiz Hany
Abstract excerpt
BACKGROUND: Hepatitis B virus (HBV) infections play an important role in the development of hepatocellular carcinoma (HCC). HBV X protein (HBx) is a multifunctional protein that can modulate various cellular processes and plays a crucial role in the pathogenesis of HCC. HBx is known to interact with DNA helicase components of TFIIH, a basal transcriptional factor and an integral component of DNA excision repair....
Topics
- Binding Sites
- DNA Repair
- Hepatitis B virus
- Hepatocytes
- Humans
- Mutagenesis, Site-Directed
- Mutation
- Protein Interaction Domains and Motifs
- Saccharomyces cerevisiae
- Trans-Activators
- Transcription Factor TFIIH